Calcium ọwa channelers

Ogwu calcium dị oke mkpa maka ijide usoro nke na-eme n'elu akpụkpọ ahụ nke nwere akụkụ intracellular. Nke a na-eme site na channelụ ion, site na nke ụfọdụ ụdị protein protein na-emeghe ụzọ maka ions calcium.

Ebe na ọrụ nke ọwa channel

A na-ekewa ọwa ndị a n'ụdị atọ:

• cytoplasmic;
• ebe ọhụụ
• intracellular.

Ihe ka ọtụtụ n'ime olulu calcium dị n'ime ahụ obi, ndị fọdụrụ n'ime anụ ahụ ahụ nke bronchi, akpanwa, akụkụ eriri afọ, urinary tract and platelets.

Dịka e kwuru na mbụ, ions calcium na-emetụta usoro ahụ metabolic ahụ, na - eme:

• mmụba n'ọchịchọ ikuku oxygen;
• arụsi ọrụ ahụ ike;
• enwekwu ume.

Iji kwụsị ọrụ a na nkà mmụta ọgwụ, ọgwụ ndị dị na ìgwè calcium channel blockers (BCC) ma ọ bụ dịka a na-akpọkwa ha na-eji ngwa ngwa ndị na-egbochi ndị na-ekpo ọkụ na calcium.

Ntuziaka maka ojiji na ọgwụgwọ BPC

A na-eji usoro ọgwụgwọ nke ndị na-egbochi ndị na-eme ka calcium bụrụ ndị na-akpata ọrịa ndị na-esonụ:

• ọbara mgbali;
• angina pectoris ;
• enweghi afọ ojuju;
• Njikọ nke angina na bradycardia;
• tachycardia;
• nsogbu ụbụrụ obi;
• nsogbu nke ụbụrụ ụbụrụ;
• mmeri nke obi nke etiology ajuju;
• Ọrịa Raynaud .

Na mgbakwunye, BPC nwere ike ịhazi maka ọrịa nke usoro ụjọ ahụ, allergies, bronchospasm na ọrịa ụfọdụ na-ekesa (ọrịa Alzheimer, nkwarụ na-egbu egbu, mmanya na-egbu egbu).

Usoro nke ime ihe nchịkwa calcium na-akpata:

• ụda olu dị nro dị ala;
• mmelite nke ọbara;
• eme ka obi ghara iru ala;
• mmetụta diuretic;
• ọnụ na ngwa ngwa;
• ọnụ na ọkwa nke platelet na mmụba nke mmejupụta ọbara.

Nhazi nke ọgwụ

Calcium channel blockers nwere ụfọdụ nhazi na-ekewa n'ime:

1. Ntugharị nke dihydropyridine. Ndị ọgwụ ndị a dabeere na nifepidine. Ha nwere mmetụta na-agbasawanye n'ahụ arịa ụbụrụ (Corinfar, Ardalat, Cordaflex, Lomir, Plendil, wdg).
2. Ihe mgbakwunye Phenylalkylamine. Otu ìgwè nke verapamil. Ha na-emetụta ahụ ike obi, na-ebelata nkwekọrịta ya. Mmetụta dị na arịa ndị ahụ adịghị ike (Isoptin, Prokorum, Finoptin).
3. Ihe mgbakwunye Benzothiazinine. Group diltiazem. Mmetụta nke ọgwụ ndị a dị ala karịa nke nke mbụ, ma a na-ekesa ya ma obi ma arịa (Dilsem, Cardil).
4. Ntugharị nke diphenylpyrazine. Otu nke cinnarizine. Ọtụtụ mgbe, a na-ede CCB ndị a maka ọnya ụbụrụ (Stugeron, Nomigrain).

Na mgbakwunye, a na-ekewa ndị na-egbochi ọwa mmiri calcium n'ime ọgbọ mbu na nke abụọ, na preparations dihydropyridine nwere nke atọ. Ihe dị iche iche dị iche n'etiti ọgbọ bụ imeziwanye ọgwụgwọ ọgwụ na mbelata ihe ndị na-adịghị mma mgbe ịṅụ ọgwụ ọjọọ. Nakwa, ọgwụ ndị nke abụọ na ọgbọ nke atọ na-ebelata ụdị ọgwụ kwa ụbọchị, ọ dịkwa ha mkpa iji nanị 1-2 ugboro n'ụbọchị. Nye ndị na-egbochi ọwa nke calcium nke ọgbọ nke atọ bụ ọgwụ ndị dị ka Amlodipine, Latsidipin, Nimodipine.

Jiri na contraindications

Nkwekọrịta nke BPC ga-ekwe omume naanị mgbe ịkọchara nkọwa na dọkịta na nyocha. Na ikpe nke ọ bụla, a na-eji ọgwụ eme ihe nke nwere ike ịmepụta ọgwụgwọ kacha mma.

Onye ọ bụla ọgwụ nwere onwe ya doro anya contraindications, ma na n'ozuzu, ha na-adịghị akwadoro maka iji mgbe:

• obi ọgụ;
• nsogbu nke cardiogenic;
• afọ ime, n'oge oge nri;
• nwata;
• onye ekweghi ekwe;
• ọrịa obi na nsogbu na akụrụ na imeju.